Her Well Journal
Cluster 3 — Botanical & Chemical Active Profile Analyses

INGREDIENT DATABASE

Before reviewing brands, we evaluate individual active components. Every compound profile breaks down oral bioavailability, metabolic and endocrine receptors, clinical dosage trials, and potential pharmaceutical drug interactions.

Biological System Filter
Compound CoreTier 1

Ashwagandha (KSM-66): Cortisol & Stress Weight Loss

A clinical review of Ashwagandha (Withania somnifera) benefits for women over 40, analyzing cortisol regulation, HPA-axis stabilization, and thyroid support.

Primary Pathway:HPA-axis regulation, GABAA receptor modulation, serum cortisol reduction
Standard Dosage Range:300 - 600 mg / Day (Standardized KSM-66 Extract)
Compound CoreTier 1

Berberine HCl: Insulin Sensitivity

A clinical review of Berberine HCl dosage, bioavailability, and cellular mechanisms (AMPK activation) for midlife glucose management and metabolic rate support.

Primary Pathway:AMPK activation, GLUT4 translocation
Standard Dosage Range:1500mg / Day
Compound CoreTier 1

Black Cohosh: Review for Hot Flashes

A clinical review of standardized Black Cohosh extract, mapping its mechanism, hypothalamic pathways, and clinical trial efficacy.

Primary Pathway:Central serotonin receptor modulation, hypothalamic thermoregulation
Standard Dosage Range:40 mg / Day
Compound CoreTier 2

Evening Primrose Oil: Review for Menopause

A clinical review of Evening Primrose Oil (Oenothera biennis) for vasomotor relief, skin barrier function, and prostaglandin pathways.

Primary Pathway:Prostaglandin E1 synthesis, delta-6-desaturase bypass, cellular membrane support
Standard Dosage Range:1000 - 2000 mg / Day (Standardized to 9% GLA)
Compound CoreTier 2

Maca Root: Review for Hormone Balance

An independent clinical review of Maca Root (Lepidium meyenii) for female hormone balance, libido, and hypothalamic-pituitary-ovarian axis support.

Primary Pathway:Hypothalamic-Pituitary-Ovarian (HPO) axis modulation, endocannabinoid system binding
Standard Dosage Range:1500 - 3000 mg / Day (Gelatinized Powder)
Compound CoreTier 1

Magnesium Glycinate: Review for Sleep

A clinical review of Magnesium Glycinate, analyzing its bioavailability, calming mechanisms, and clinical efficacy in improving deep sleep.

Primary Pathway:Central GABA-A receptor agonism, NMDA receptor antagonism
Standard Dosage Range:300 - 400 mg / Day (Elemental Magnesium)
Compound CoreTier 1

Rhodiola Rosea: Review for Menopause Fatigue

A clinical review of Rhodiola Rosea benefits for menopause fatigue, HPA-axis stabilization, and cortisol-related energy recovery.

Primary Pathway:HPA-axis modulation, AMPK activation, monoamine oxidase (MAO) inhibition, neuropeptide Y (NPY) regulation
Standard Dosage Range:200 - 400 mg / Day (Standardized to 3% Rosavins and 1% Salidroside)
Compound CoreTier 2

Vitex Agnus Castus: Review for Perimenopause

A clinical review of Vitex Agnus Castus (Chasteberry) for perimenopausal progesterone support, prolactin regulation, and luteinizing hormone stabilization.

Primary Pathway:Dopamine D2 receptor agonism, pituitary prolactin inhibition, LH secretion stimulation
Standard Dosage Range:20 - 40 mg / Day (Standardized Extract)